The west is tougher to fish, but you have the most beautiful mountains (and trout) anywhere in the country. I almost forgot to include the area where I'm from, Northwestern Colorado. Awesome mountain fishing for cutts and brookies, lower down you have rainbows, browns, pike, and some surprisingly nice smallmouth bass. Not to mention the best scenery I've ever experienced, between the high plains, foothills, and the true high country. I am biased though. I have never been to Alaska, but that's where my folks are from, specifically from a tiny town in the interior, somewhat north of Fairbanks. They say nothing in the lower 48 can compare. I really need to get up there soon, but realistically it would just be too expensive.
The ozarks are most certainly beautiful as well. It's pretty in a different kind of way than Rocky Mountain west though, more charming than breathtaking. Personally, I need a bit of both. We certainly are blessed with an amazing variety of fish, so I'm most certainly not complaining.