Well, you usually want the line to come off the spool counter clockwise which usually means label up. But even by doing it that way you are still going to get some twist. Just let 100 yards or so drift down current without a lure tied on and slowly reel it back in: this definitely helps. I also spray some of the Kevin Van Dam reel and line conditioner on it, makes it last longer and cast better too. A guide taught me a good trick many years ago to keep from getting blow ups with your spinning reel. After you cast and the bail flips over, tug on the line about 6" above the reel to eliminate any small loops before you start reeling it back in. This could possibly save your spool on the next cast.