Trust me. I have tried neosporin, as well as about 5 different moisturizing lotions, Husker Lotion, Aquaphor lotion.....nothing has really worked. Some have helped but I've had this dry patch of skin on finger print area of my thumb going on 3 years now. During the late spring and summer it softens up and is fine. When cold hits it drys out and eventually splits into a cut. Very frustrating.