When I planned to hunt with a particular caliber, I would buy a new rifle and a good Leupold scope. I’d bore sight it and head for the range. For the first 100 rounds I really didn’t care much about accuracy. I would shoot 5 rounds then clean the barrel. After each set of 3 5 shot rounds I would use Sweets to really clean the bore. After 100 rounds I would start developing a load. Normally 15 rounds of a particular load would give me enough data. As I got closer to good groups with a particular load I would tweak it by changing primers and amounts of powder.
My goal was sub minute groups at 100 yards. When that was achieved, I would start zeroing in the scope. After that process was complete, I moved out to 200 yards and finalized my settings.