At Hams recommendation I gave Nanofil a shot this year. After two trips I took it off. The stuff is worthless in the wind. Alberto knot is great.
Straight 4 pound flouro for trout fishing, 10 pound on a medium spinning rod for flukes and stuff and 6 pound for the Ned on a St Croix rod Ham and Dave recommended. I love that St Croix Rod as much as my Helios flyrod.