I grew up fishing the upper Little Niangua passed Big Island...maybe a couple miles from the Hwy J bridge. We would be out on 4th of July weekend fishing out of paddle-boats, kayaks, and 12' john boats and never felt unsafe. Don't think we ever saw a cruiser up that far. Even as kids, we always caught a lot of fish.
You are 20-30 minutes from Camdenton.