Well, I prefer Nanofil because it out throws mono and it has almost no stretch so it is super sensitive and I get great hook sets and any distance. I use the White, but I would be comfortable using the chartreuse as well. The opaque colors don't bother the fish when I use a leader and they I also help you detect strikes.
I use the leader because I am concerned that the Nanofil might reduce my number of bites and I want to extend the life of my Nanofil. It also doesn't hurt to have a leak link when you get hung up and WANT to break off.
I use mono under the Nanofil and I am able to get two or three reels spooled with one 150 yard spool of Nanofil. I have used one spooling of nano for over a year w/o any problems.
I use an Alberto knot to join my line to the leader. I tie in a piece of leader just long enough that the knot is not on the reel. I re tie when needed. I will use it until the leader length is down to 18 inches or so.
I have used just the P Line CX or Silver Thread AN 40 as the main line and I caught fish just fine, but Nanofil has flat out made me a better fisherman. I think I have been using for about 18 months and I am an absolute believer in it.
I also used braid for a while, but I lost casting distance using it. I dropped down to 4/15 and still struggled to throw it 2/3's the distance of mono, but I liked the lack of stretch. Nanofil is strong for its diameter, but it is thicker than braid on a per pound basis. Nanofil is thinner than mono on a pound per pound basis.
Nanofil isn't perfect. It catches the wind a little bit more than mono and it gets twist in it and it is a little more difficult to de twist than mono is, but I have just about switched all my spinning gear over to Nanofil.
Ham