I think the 10/22 comments are more related to cheap, plentiful, quick follow up, and not the rifle that you're afraid to get knocked around a little.
.22 LR isn't normally considered a 100 yard round, mostly due to exterior ballistics. If you zero at 50 yards, they drop somewhere around 5 to 6 inches at 100 yards and wind moves them around pretty good too. By comparison, .22WMR zeroed at 50 yards drops less than 2 inches. That's easily the difference between a hit and a miss. Sure you can hold over with .22LR but you need to practice to know how much at various ranges.