If I am standing still, then it's definitely easier to fish the middle of a pool versus the riffle, but not so much when drifting in a boat. As long as the boat is moving at the same speed as the current, it doesn't really matter much. Throw at a 45 degree angle down stream and it's not much different than jigging dead water to me. I'd rather fish nose down when going with the current versus nose up unless I am trying to target eddies.
I imagine I'm in for a bit of a learning curve on the White the way it sounds and I can't wait to get down there and try to figure things out.